Topoisomerase 3B (TOP3B) DNA and RNA Cleavage Complexes and Pathway to Repair TOP3B-linked RNA and DNA Breaks
S. Saha, S.-Y. Huang, U. Jo, H. Zhang, Y.-C. Tse-Dinh, Y. Pommier
The paper identifies a pathway for repairing TOP3B DNA and RNA cleavage complexes, showing that TDP2 excises ubiquitinated TOP3Bccs after proteasomal degradation.
bioRxiv · Mar 22, 2020Cell Biology