Inactivation mechanisms of Influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS.
S. C. David, O. Vadas, I. Glas, A. Schaub, B. Luo, G. C. D'Angelo, J. Paz Montoya, N. Bluvshtein, W. Hugentobler, L. Klein, G. Motos, M. Pohl, K. Violaki, A. Nenes, U. Krieger, , T. Kohn
This study identifies how Influenza A virus inactivates under acidic aerosol conditions using HDX-MS, revealing HA conformational changes and M1 unfolding as key mechanisms.
bioRxiv · Nov 1, 2022Microbiology