Author

O. Vadas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1

Frequent Co-Authors

D. Soldati-Favre· 4 shared N. Dos Santos Pacheco· 2 shared A. Batiuk· 1 shared A. C. Almeida· 1 shared A. Gandhirajan· 1 shared A. Krishnan· 1 shared A. Kumar· 1 shared A. Nenes· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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4 shared papersMicrobiology

D. Soldati-Favre

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay

A. Batiuk, M. Höpfler, A. C. Almeida, D. T. En-Jie, O. Vadas, E. Vartholomaiou, R. S. Hegde, Z. Lin, I. Gasic

The paper shows soluble β-tubulins sequester TTC5 to regulate tubulin mRNA decay, with loss of sequestration leading to reduced mRNA levels and chromosome segregation defects.

bioRxiv · Apr 12, 2024Cell Biology

Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

A. Kumar, O. Vadas, N. Dos Santos Pacheco, X. Zhang, K. Chao, N. Darvill, H. Rasmussen, Y. Xu, G. Lin, F. Stylianou, J. S. Pedersen, S. Rouse, M. Morgan, D. Soldati-Favre, S. Matthews

This study presents the crystal structure of Toxoplasma gondii GAC and proposes a multi-conformational model for its assembly in the glideosome.

bioRxiv · Jan 23, 2023Biochemistry

Inactivation mechanisms of Influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS.

S. C. David, O. Vadas, I. Glas, A. Schaub, B. Luo, G. C. D'Angelo, J. Paz Montoya, N. Bluvshtein, W. Hugentobler, L. Klein, G. Motos, M. Pohl, K. Violaki, A. Nenes, U. Krieger, , T. Kohn

This study identifies how Influenza A virus inactivates under acidic aerosol conditions using HDX-MS, revealing HA conformational changes and M1 unfolding as key mechanisms.

bioRxiv · Nov 1, 2022Microbiology

Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

P. Juyoux, I. Galdadas, D. Gobbo, J. von Velsen, M. Pelosse, M. Tully, O. Vadas, F. L. Gervasio, E. Pellegrini, M. W. Bowler

The paper determines the structure and activation mechanism of the MKK6-p38α complex using cryo-EM and MD simulations, revealing how phosphorylation and interactions drive MAPK specificity.

bioRxiv · Jul 4, 2022Biophysics

Conoid extrusion serves as gatekeeper for entry of glideosome components into the pellicular space to control motility and invasion in Apicomplexa

N. Dos Santos Pacheco, L. Brusini, R. Haase, N. Tosetti, B. Maco, M. Brochet, O. Vadas, D. Soldati-Favre

The paper identifies new components of the conoid in Apicomplexa and shows it regulates glideosome assembly and motility by controlling F-actin flux.

bioRxiv · Jun 6, 2022Microbiology

Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii

M. Lunghi, J. Kloehn, A. Krishnan, E. Varesio, O. Vadas, D. Soldati-Favre

This study shows that pantothenate biosynthesis is critical for chronic Toxoplasma gondii infection, while CoA synthesis is essential for acute stages.

bioRxiv · Oct 4, 2021Microbiology

Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation

M. K. Rathinaswamy, U. Dalwadi, K. D. Fleming, C. Adams, J. T. Stariha, E. Pardon, M. Baek, O. Vadas, F. DiMaio, J. Steyaert, S. D. Hansen, C. K. Yip, J. E. Burke

The paper reports the cryo-EM structure of the p110γ-p101 complex, revealing how GPCR activation is mediated through interactions with Gβγ and identifying potential therapeutic targets.

bioRxiv · Jun 1, 2021Biochemistry

Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b

L.-J. Chan, A. Gandhirajan, L. L. Carias, M. H. Dietrich, O. Vadas, R. Visentin, C. T. Franca, S. Menant, D. Soldati-Favre, I. Mueller, C. L. King, W.-H. Tham

The paper isolates and characterizes human monoclonal antibodies against PvRBP2b that block its function in P. vivax invasion.

bioRxiv · May 12, 2020Microbiology