FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
U. Künzel, A. G. Grieve, Y. Meng, S. A. Cowley, M. Freeman
This study identifies FRMD8 as a stabilizer of the iRhom2/ADAM17 complex, essential for ADAM17-mediated shedding of cytokines and growth factors.
bioRxiv · Jan 30, 2018Biochemistry