Author

S. A. Cowley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Immunology· 3 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Organism:human· 8 Research Focus:cell type annotation· 5 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2

Frequent Co-Authors

W. S. James· 5 shared C. Browne· 3 shared J. Vowles· 2 shared A. G. Grieve· 1 shared A. J. Russell· 1 shared A. R. Bassett· 1 shared A. T. Hanrath· 1 shared A. Taylor· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersImmunology

W. S. James

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Functional Integration of 3D-Printed Cerebral Cortical Tissue into a Brain Lesion

Y. Jin, E. Mikhailova, M. Lei, S. A. Cowley, T. Sun, X. Yang, Y. Zhang, K. Liu, D. Catarino, L. C. Soares, S. Bandiera, F. G. Szele, Z. Molnar, L. Zhou, H. Bayley

This study develops 3D-printed cerebral cortical tissues with layer-specific organization and integration into mouse brain explants, showing neuronal connectivity and potential for personalized medicine.

bioRxiv · Oct 28, 2022 · PreprintBioengineering

Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSCs to microglia

S. J. Washer, M. Perez-Alcantara, Y. Chen, J. Steer, W. S. James, A. R. Bassett, S. A. Cowley

The paper identifies redundant medium components in iPSC differentiation to microglia using single-cell RNA sequencing and provides an optimized protocol for generating functional microglia.

bioRxiv · Aug 2, 2022Immunology

Type I interferons govern Zika virus resistance of human macrophages and microglia

A. T. Hanrath, C. F. Hatton, F. Gothe, C. Browne, J. Vowles, P. Leary, S. J. Cockell, S. A. Cowley, W. S. James, S. Hambleton, C. J. A. Duncan

This study shows that type I interferons restrict Zika virus replication in macrophages and microglia, and their suppression increases viral replication and cell damage.

bioRxiv · Mar 9, 2022 · PreprintCell Biology

Differentiation of Human induced Pluripotent Stem Cells to Authentic Macrophages using Fully Defined, Serum Free, Open Source Media

A. Vaughan-Jackson, S. Stodolak, K. H. Ebrahimi, C. Browne, P. K. Reardon, E. Pires, J. Gilbert-Jaramillo, S. A. Cowley, W. S. James

This paper describes two fully defined, serum-free, open-source media for culturing human iPSCs and differentiating them into macrophages, showing improved characteristics compared to commercial media.

bioRxiv · Oct 27, 2020Immunology

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

J. Toombs, L. Panther, L. Ornelas, C. Liu, E. Gomez, R. Martinibanez, S. R. Cox, S. J. Ritchie, S. E. Harris, A. Taylor, P. Redmond, T. C. Russ, L. Murphy, J. D. Cooper, K. Burr, , D. Sareen

The paper generates 24 induced pluripotent stem cell lines from members of the Lothian Birth Cohort 1936 to study cognitive ageing and neurodegenerative disease resilience.

bioRxiv · Feb 5, 2020Cell Biology

A chemical tool for improved culture of human pluripotent stem cells

L. Silpa, M. Schuessler, G. Liu, M. Olivecrona, L. Groizard-Payeras, E. Couper, C. J. R. Bataille, M. Stevenson, L. W. Seymour, S. G. Davies, W. S. James, S. A. Cowley, A. J. Russell

This paper identifies a small molecule, OXS8360, that improves the culture of human pluripotent stem cells by disrupting cell-cell contacts without affecting pluripotency or differentiation.

bioRxiv · Jan 24, 2020 · PreprintCell Biology

LRRK2 is recruited to phagosomes and co-recruits Rab8 and Rab10 in human pluripotent stem cell-derived macrophages

H. Lee, R. Flynn, I. Sharma, P. J. Carling, F. J. Nicholls, M. Stegmann, J. Vowles, R. Wade-Martins, W. S. James, S. A. Cowley

This study shows LRRK2 is recruited to maturing phagosomes and required for Rab8a and Rab10 recruitment in human macrophages.

bioRxiv · Sep 25, 2019Immunology

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

U. Künzel, A. G. Grieve, Y. Meng, S. A. Cowley, M. Freeman

This study identifies FRMD8 as a stabilizer of the iRhom2/ADAM17 complex, essential for ADAM17-mediated shedding of cytokines and growth factors.

bioRxiv · Jan 30, 2018Biochemistry