Author

U. Langel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

K. Kurrikoff· 2 shared P. Arukuusk· 2 shared A. Kuznetsov· 1 shared B. Vunk· 1 shared C. P. Cerrato· 1 shared E. Juronen· 1 shared H. H. Hark· 1 shared H. Härk· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

K. Kurrikoff

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Expressed therapeutic protein yields are predicted by transiently transfected mammalian cell population

L. Porosk, J. Nebogatova, H. H. Hark, B. Vunk, P. Arukuusk, U. Toots, M. Toots, U. Langel, K. Kurrikoff

The paper compares transfection reagents in mammalian cell cultures to predict therapeutic protein yields, finding CPP-based methods outperform PEI and lipoplex.

bioRxiv · Mar 15, 2022Biochemistry

ACE2 peptide fragment interacts with several sites on the SARS-CoV-2 spike protein S1

A. Kuznetsov, P. Arukuusk, H. Härk, E. Juronen, U. Langel, M. Ustav, J. Järv

The paper studies how a specific ACE2 peptide fragment affects S1-ACE2 complex formation and identifies additional binding sites on the S1 protein.

bioRxiv · Dec 29, 2020 · PreprintBiochemistry

Viability and mitochondrial bioenergetic functions in human colon cancer cells are not affected by treatment with peptides mtCPP1, UPF25, mtgCPP, and mtCPP1gHO

N. Timohhina, C. P. Cerrato, K. Kurrikoff, V. Chekulayev, J. Aid-Vanakova, M. Puurand, K. Tepp, I. Shevchuk, U. Langel, T. Kaambre

This study examines the effects of four mitochondrially targeted antioxidant peptides on viability and mitochondrial function in Caco-2 cells, finding no significant impact on mitochondrial bioenergetics or cell viability.

bioRxiv · Jul 3, 2020 · PreprintCancer Biology

Mimicry of dopamine 1 receptor signaling with Cell-Penetrating Peptides

N. Lorenzon, M. Gestin, U. Langel

This study develops a peptide that mimics dopamine 1 receptor signaling and can substitute L-DOPA, showing efficient cell penetration and activation of the receptor pathway.

bioRxiv · Jan 7, 2020Pharmacology & Toxicology