Author

M. Toots

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. R. Painter· 2 shared J. Sourimant· 2 shared J.-J. Yoon· 2 shared M. Aggarwal· 2 shared M. G. Natchus· 2 shared R. Cox· 2 shared R. K. Plemper· 2 shared A. A. Kolykhalov· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMicrobiology

G. R. Painter

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

C. M. Lieber, M. Aggarwal, J.-J. Yoon, R. Cox, J. Sourimant, M. Toots, H.-J. Kang, S. K. Johnson, C. A. Jones, Z. M. Sticher, A. Kolykhalov, M. T. Sindaine, S. M. Tompkins, O. Planz, G. R. Painter, , R. K. Plemper

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

bioRxiv · Nov 5, 2022 · PreprintMicrobiology

Expressed therapeutic protein yields are predicted by transiently transfected mammalian cell population

L. Porosk, J. Nebogatova, H. H. Hark, B. Vunk, P. Arukuusk, U. Toots, M. Toots, U. Langel, K. Kurrikoff

The paper compares transfection reagents in mammalian cell cultures to predict therapeutic protein yields, finding CPP-based methods outperform PEI and lipoplex.

bioRxiv · Mar 15, 2022Biochemistry

4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

J. Sourimant, C. Lieber, M. Aggarwal, R. Cox, J. Wolf, J.-J. Yoon, M. Toots, C. Ye, Z. Sticher, A. A. Kolykhalov, L. Martinez-Sobrido, G. R. Bluemling, M. G. Natchus, G. R. Painter, R. K. Plemper

This paper identifies 4'-Fluorouridine as an orally effective antiviral that inhibits RSV and SARS-CoV-2 replication in vivo.

bioRxiv · May 19, 2021 · PreprintMicrobiology