Author

U. S. Singh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

C. De· 2 shared C. K. Chu· 2 shared D. Liu· 2 shared J. F. Moffat· 2 shared C. Hartline· 1 shared D. Depledge· 1 shared J. Breuer· 1 shared M. Prichard· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersMicrobiology

C. De

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2 papers

Recent·Most cited

β-L-1- Uracil (L-BHDU) Inhibits Varicella Zoster Virus Replication by Depleting the Cellular dTTP Pool

C. De, D. Liu, U. S. Singh, C. K. Chu, J. F. Moffat

This study shows L-BHDU inhibits VZV replication by depleting dTTP, suggesting it targets viral DNA synthesis rather than cellular metabolism.

bioRxiv · Feb 13, 2020 · PreprintMicrobiology

β-L-1- uracil (L-BHDU) effectiveness against varicella-zoster virus and herpes simplex virus type 1 depends on thymidine kinase activity

C. De, D. Liu, D. Depledge, J. Breuer, U. S. Singh, C. Hartline, M. Prichard, C. K. Chu, J. F. Moffat

This study shows L-BHDU's effectiveness against VZV and HSV-1 relies on thymidine kinase activity, as resistant strains have mutations in TK that impair drug phosphorylation.

bioRxiv · Feb 13, 2020 · PreprintMicrobiology