Author

J. F. Moffat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 1

Frequent Co-Authors

D. Liu· 3 shared C. De· 2 shared C. K. Chu· 2 shared M. G. Lloyd· 2 shared U. S. Singh· 2 shared B. A. Kashemirov· 1 shared C. E. McKenna· 1 shared C. Hartline· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

D. Liu

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Author profile →

4 papers

Recent·Most cited

An Acyclic Phosphonate Prodrug of HPMPC is Effective Against VZV in Skin Organ Culture and Mice

M. G. Lloyd, D. Liu, J. Lyu, J. Fan, J. Overhulse, B. A. Kashemirov, M. N. Prichard, C. E. McKenna, J. F. Moffat

This study develops and evaluates USC-373, a phosphonate prodrug of HPMPC, showing efficacy against VZV in cell cultures and mouse models with improved potency and bioavailability.

bioRxiv · Jan 30, 2022Microbiology

β-L-1- Uracil (L-BHDU) Inhibits Varicella Zoster Virus Replication by Depleting the Cellular dTTP Pool

C. De, D. Liu, U. S. Singh, C. K. Chu, J. F. Moffat

This study shows L-BHDU inhibits VZV replication by depleting dTTP, suggesting it targets viral DNA synthesis rather than cellular metabolism.

bioRxiv · Feb 13, 2020 · PreprintMicrobiology

β-L-1- uracil (L-BHDU) effectiveness against varicella-zoster virus and herpes simplex virus type 1 depends on thymidine kinase activity

C. De, D. Liu, D. Depledge, J. Breuer, U. S. Singh, C. Hartline, M. Prichard, C. K. Chu, J. F. Moffat

This study shows L-BHDU's effectiveness against VZV and HSV-1 relies on thymidine kinase activity, as resistant strains have mutations in TK that impair drug phosphorylation.

bioRxiv · Feb 13, 2020 · PreprintMicrobiology

Blocking the alternative sigma factor RpoN reduces virulence of Pseudomonas aeruginosa isolated from cystic fibrosis patients and increases antibiotic sensitivity in a laboratory strain

M. G. Lloyd, J. L. Vossler, C. T. Nomura, J. F. Moffat

bioRxiv · Jun 6, 2018Microbiology