Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning
A. Fogli Iseppe, H. Ni, S. Zhu, X. Zhang, R. Coppini, P.-C. Yang, U. Srivatsa, C. E. Clancy, A. G. Edwards, S. Morotti, E. Grandi
This paper develops sex-specific TdP risk classifiers using cardiac simulations and machine learning, finding that male-based models underestimate female TdP risk.
Clinical Pharmacology & Therapeutics · Apr 19, 2021Peer-reviewedPharmacology & Toxicology