Author

P.-C. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

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Research Focus:drug response / drug discovery· 4 Approach:deep learning· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

C. E. Clancy· 4 shared I. Vorobyov· 2 shared V. Yarov-Yarovoy· 2 shared A. Fogli Iseppe· 1 shared A. G. Edwards· 1 shared C. Matsumoto· 1 shared C.-C. Chang· 1 shared E. Grandi· 1 shared

Activity by Year

2019-2024 · peak 1/yr

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10 top collaborators · 16 mutual co-author links

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4 shared papersBiophysics

C. E. Clancy

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Author profile →

5 papers

Recent·Most cited

Harnessing AlphaFold to reveal hERG channel conformational state secrets

K. Ngo, P.-C. Yang, V. Yarov-Yarovoy, C. E. Clancy, I. Vorobyov

This paper uses AlphaFold to predict discrete conformational states of hERG channels, revealing structural features and drug interactions that improve drug safety screening.

bioRxiv · Jan 27, 2024Biophysics

A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

G. Hernandez Hernandez, S. C. O'Dwyer, C. Matsumoto, M. Tieu, Z. Fong, P.-C. Yang, T. J. Lewis, L. F. Santana, C. E. Clancy

The paper develops a computational model to predict sex-specific responses to calcium channel blockers in arterial smooth muscle, revealing differences in ion channel regulation between male and female myocytes.

bioRxiv · Jun 24, 2023Physiology

HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

W.-J. Luo, S.-L. Yu, C.-C. Chang, M.-H. Chien, K.-M. Liao, Y.-L. Chang, Y.-H. Chuang, J. J. W. Chen, P.-C. Yang, K.-Y. Su

This study shows HLJ1 promotes IL-12 heterodimerization in macrophages, worsening sepsis severity, and suggests targeting HLJ1 could treat IL-12/IFN-γ-related diseases.

bioRxiv · Jan 5, 2022Immunology

Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning

A. Fogli Iseppe, H. Ni, S. Zhu, X. Zhang, R. Coppini, P.-C. Yang, U. Srivatsa, C. E. Clancy, A. G. Edwards, S. Morotti, E. Grandi

This paper develops sex-specific TdP risk classifiers using cardiac simulations and machine learning, finding that male-based models underestimate female TdP risk.

bioRxiv · Oct 26, 2020Pharmacology & Toxicology

Atomistic modeling towards predictive cardiotoxicity

K. R. DeMarco, J. R. D. Dawson, P.-C. Yang, S. Bekker, V. A. Ngo, S. Y. Noskov, V. Yarov-Yarovoy, C. E. Clancy, I. Vorobyov

This paper develops a computational framework to distinguish safe and unsafe hERG blockers by modeling atomic interactions and simulating drug-channel dynamics.

bioRxiv · May 11, 2019 · PreprintBiophysics