Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.
John Kenneth Baillie, Andrew D. Bretherick, Chris Haley, Sara Clohisey, Alan Gray, Lucile P. A. Neyton, Jeffrey C. Barrett, Eli A. Stahl, Albert Tenesa, Robin Andersson, James B. Brown, Geoffrey J. Faulkner, Marina Lizio, Ulf Schaefer, Carsten O. Daub, , David Arthur Hume
The paper identifies shared expression patterns of genetic variants across tissues and cell types, enabling fine mapping of disease-associated variants and revealing key cell types involved in disease pathogenesis.
PLoS Computational Biology · Mar 1, 2018Peer-reviewedGenomics