Andrew D. Bretherick

Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome

This study conducts a genome-wide association study (GWAS) of ME/CFS, identifying eight genetic loci associated with the disease, suggesting involvement of immune and neurological processes.

Leveraging molecular-QTL co-association to predict novel disease-associated genetic loci using a graph convolutional neural network

Dual site proteomic analyses reveal potential drug targets for cardiovascular disease

This paper uses Mendelian randomisation to identify potential drug targets for cardiovascular disease by analysing protein levels in plasma and PBMCs from large cohorts.

Genetic control of KRAB-ZFP genes explains distal CpG-site methylation which associates with human disease phenotypes.

The paper identifies KRAB-ZFP genes' influence on CpG-site methylation and links these methylation patterns to disease phenotypes like rheumatoid arthritis and HIV infection.

Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome

This study identifies modifiable parent-of-origin effects on DNA methylation by analyzing genetic and environmental factors in a large cohort.

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

Identification of epigenome-wide DNA methylation differences between carriers of APOE ϵ4 and APOE ϵ2

This study identifies epigenome-wide DNA methylation differences between APOE ε4 and ε2 carriers in whole blood, implicating lipid-related genes.

Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

The paper identifies pQTLs for cardiovascular proteins and uses them to evaluate drug targets and suggest new candidates for precision medicine.

Epigenome-wide analyses identify DNA methylation signatures of dementia risk

The paper identifies DNA methylation signatures associated with dementia risk factors in blood samples from individuals without Alzheimer's disease.

Genomic underpinnings of lifespan allow prediction and reveal basis in modern risks

The paper identifies genetic loci associated with lifespan using genome-wide association and shows that variants linked to modern diseases explain most lifespan variation.

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

The paper identifies shared expression patterns of genetic variants across tissues and cell types, enabling fine mapping of disease-associated variants and revealing key cell types involved in disease pathogenesis.