John Kenneth Baillie

This study integrates multiomic data to identify cell-type-specific pathways and therapeutic targets in early Alzheimer's disease.

This study identifies key host genes in chicken cells critical for influenza A virus replication using CRISPR-Cas9 screens, revealing conserved and species-specific factors.

The paper shows that disease-associated variants in alternative protein isoforms can cause structural mutations, emphasizing the need to consider tissue-specific expression and full-length transcripts in variant interpretation.

The paper identifies manufacturing plasmid sequences and disrupted vector genomes in liver tissue from a patient with AAV gene therapy-related hepatitis.

This paper uses Mendelian randomisation to identify potential drug targets for cardiovascular disease by analysing protein levels in plasma and PBMCs from large cohorts.

This study compares ranking aggregation methods for gene lists using simulated and real data to evaluate their performance in meta-analyses.

The paper identifies KRAB-ZFP genes' influence on CpG-site methylation and links these methylation patterns to disease phenotypes like rheumatoid arthritis and HIV infection.

The paper identifies an alternative splicing variant of OAS1 that provides protection against severe COVID-19 in people of African ancestry, independent of Neanderthal haplotypes.

This paper identifies a common TMPRSS2 variant that reduces the risk of severe COVID-19 by impairing SARS-CoV-2 entry into cells.

The paper develops a machine learning model to predict COVID-19 severity using exonic variants from whole exome sequencing data, finding that variants across all frequency categories contribute to severity.

The paper identifies widespread transcription initiation at microsatellites across species and develops deep learning models to predict STR-associated transcription and its impact on disease variants.

This paper systematically reviews and meta-analyzes host factors in COVID-19 to identify potential therapeutic targets and genes associated with disease.

The paper identifies four distinct endotypes in acute pancreatitis using multiomic data and clinical metrics, showing diverse molecular and systemic responses.

This study shows segmented negative-strand RNA viruses use upstream translation initiation to expand their coding capacity through non-AUG initiation and host mRNA leader sequence appropriation.

The paper identifies shared expression patterns of genetic variants across tissues and cell types, enabling fine mapping of disease-associated variants and revealing key cell types involved in disease pathogenesis.