Sara Clohisey

Dual site proteomic analyses reveal potential drug targets for cardiovascular disease

This paper uses Mendelian randomisation to identify potential drug targets for cardiovascular disease by analysing protein levels in plasma and PBMCs from large cohorts.

Systematic review and meta-analysis identifies potential host therapeutic targets in COVID-19.

This paper systematically reviews and meta-analyzes host factors in COVID-19 to identify potential therapeutic targets and genes associated with disease.

Upstream translation initiation expands the coding capacity of segmented negative-strand RNA viruses

This study shows segmented negative-strand RNA viruses use upstream translation initiation to expand their coding capacity through non-AUG initiation and host mRNA leader sequence appropriation.

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

The paper identifies shared expression patterns of genetic variants across tissues and cell types, enabling fine mapping of disease-associated variants and revealing key cell types involved in disease pathogenesis.