Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14
J. Shirian, V. Arkadash, I. Cohen, T. Sapir, E. S. Radisky, N. Papo, J. M. Shifman
The paper engineers a specific inhibitor for MMP-9 and MMP-14 from a broad MMP inhibitor using computational design and yeast surface display, showing enhanced specificity and structural insights.
bioRxiv · Dec 31, 2017Biophysics