Author

J. Shirian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

E. S. Radisky· 2 shared I. Cohen· 2 shared J. M. Shifman· 2 shared N. Papo· 2 shared M. Heyne· 1 shared T. Sapir· 1 shared V. Arkadash· 1 shared Y. Peleg· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

E. S. Radisky

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

M. Heyne, J. Shirian, I. Cohen, Y. Peleg, E. S. Radisky, N. Papo, J. M. Shifman

This study quantifies mutational effects on binding affinity in three homologous protease-inhibitor complexes, revealing distinct binding landscapes and epistasis patterns.

bioRxiv · Oct 14, 2020Biophysics

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14

J. Shirian, V. Arkadash, I. Cohen, T. Sapir, E. S. Radisky, N. Papo, J. M. Shifman

The paper engineers a specific inhibitor for MMP-9 and MMP-14 from a broad MMP inhibitor using computational design and yeast surface display, showing enhanced specificity and structural insights.

bioRxiv · Dec 31, 2017Biophysics