V. Benn

In Vivo Efficacy and PK/PD Modeling of KBP-7072, An Aminomethylcycline Antibiotic, in Neutropenic Pneumonia and Thigh Infection Models

This study evaluates the in vivo efficacy and PK/PD of KBP-7072, an aminomethylcycline antibiotic, in pneumonia and thigh infection models, showing significant dose-dependent reductions in CFUs and improved survival.

The third-generation tetracycline, KBP-7072, exploits and reveals a new potential of the primary tetracycline binding pocket

This study determines the structure of KBP-7072 bound to the 30S ribosomal subunit, showing it inhibits protein synthesis by binding to the primary tetracycline site and interacting uniquely with the subunit.