A. Schedlbauer

Unpacking Unstructured Data: A Pilot Study on Extracting Insights from Neuropathological Reports of Parkinson's Disease Patients using Large Language Models

This study uses large language models to structure unstructured neuropathological reports from Parkinson's disease patients, improving data consistency and enabling integration with clinical and genetic data.

Thermodynamic Stabilization of Human Frataxin

This study thermodynamically stabilizes human frataxin using computational methods, improving its stability and resistance to proteolysis without compromising function.

Orthoformimycin inhibits translation elongation by displacing the A-site tRNA and preventing peptide bond formation

This study investigates how orthoformimycin inhibits translation elongation by displacing the A-site tRNA and blocking peptide bond formation using X-ray crystallography and kinetic analysis.

A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit

The paper uses cryo-EM to study bacterial ribosome assembly factors and identifies a conserved rRNA switch involved in decoding site maturation.

The third-generation tetracycline, KBP-7072, exploits and reveals a new potential of the primary tetracycline binding pocket

This study determines the structure of KBP-7072 bound to the 30S ribosomal subunit, showing it inhibits protein synthesis by binding to the primary tetracycline site and interacting uniquely with the subunit.