AATF/Che-1, a new component of paraspeckles, controls R-loops formation and Interferon activation in Multiple Myeloma.
T. Bruno, G. Corleone, C. Cortile, F. de Nicola, V. Catena, F. Fabbretti, S. Gumenyuk, F. Pisani, A. Mengarelli, C. Passananti, M. Fanciulli
This study identifies Che-1/AATF as a paraspeckle component that regulates R-loop formation and interferon activation in multiple myeloma, linking R-loops to disease progression and poor prognosis.
bioRxiv · Aug 4, 2021 · PreprintCell Biology