Glycolytic inhibitor 2-Deoxy-D-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions
A. N. Bhatt, A. Kumar, Y. Rai, N. Kumari, D. Vedagiri, K. H. Harshan, V. Chinnadurai, S. Chandna
This study shows that 2-Deoxy-D-glucose inhibits SARS-CoV-2 replication by blocking glycolysis and causing unglycosylation of the spike protein, reducing viral infectivity.
bioRxiv · Jun 12, 2021Cell Biology