K. H. Harshan

Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology

This study uses transgenic mouse models to show that a heightened type 1 IFN response protects against SARS-CoV-2-induced immunopathology, with Irgm1 as a potential therapeutic target.

SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses

This study shows that the SARS-CoV-2 Delta variant suppresses innate immune responses and evades interferon activation more effectively than earlier variants.

Metformin Suppresses SARS-CoV-2 in Cell Culture

This study shows metformin inhibits SARS-CoV-2 growth in cell culture by activating AMPK, reducing viral titers by up to 99%.

Regulation of eIF2α Phosphorylation by MAPKs Influences Polysome Stability and Protein Translation

This study shows that p38 MAPK and ERK1/2 regulate polysome stability and translation through integrated stress response pathways, with dual inhibition causing significant polysome collapse.

Glycolytic inhibitor 2-Deoxy-D-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions

This study shows that 2-Deoxy-D-glucose inhibits SARS-CoV-2 replication by blocking glycolysis and causing unglycosylation of the spike protein, reducing viral infectivity.

SARS-CoV-2 Infection Causes Strong mTORC1 Inhibition and Massive Polysome Collapse

This study shows SARS-CoV-2 infection inhibits mTORC1 and causes polysome collapse, but not through eIF2 phosphorylation, and allows viral mRNA translation while suppressing host mRNA translation.

N440K variant of SARS-CoV-2 has Higher Infectious Fitness

The paper investigates the N440K variant of SARS-CoV-2, finding it produces significantly higher infectious titers than two other strains in cell cultures.

Inactivation of SARS-CoV-2 by β-propiolactone Causes Aggregation of Viral Particles and Loss of Antigenic Potential

This study examines the effects of β-propiolactone on SARS-CoV-2 inactivation, finding that higher concentrations cause protein loss, antigenic degradation, and virion aggregation.

Development of Equine Immunoglobulin Fragment F(ab')2 with High Neutralizing Capability against SARS-CoV-2

This study develops equine-derived F(ab')2 antibodies with high neutralizing capability against SARS-CoV-2, showing effectiveness against viral variants.

Retinoic Acid Inducible Gene-I like Receptors Activate Snail and Slug to Limit RNA Viral Infections

The paper shows that RLRs activate Snail and Slug to limit RNA viral infections by regulating their transcription and enhancing the antiviral response.