Troriluzole Rescues Glutamatergic Deficits, Amyloid and Tau Pathology, and Synaptic and Memory Impairments in 3xTg-AD Mice
J. Pfitzer, P. D. Pinky, S. Perman, E. Redmon, L. Cmelak, V. Suppiramaniam, V. Coric, I. A. Qureshi, M. W. Gramlich, M. N. Reed
This study shows troriluzole reduces glutamate release and cognitive deficits in 3xTg-AD mice by targeting presynaptic changes linked to AD pathology.
bioRxiv · Jun 11, 2024Pharmacology & Toxicology