ImmunologybioRxivPreprint
A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8+ T Cells
E. C. Lerner, K. Woroniecka, V. D'Anniballe…·P. E. Fecci
This study shows CD8+ T cells can kill MHC-I-deficient tumor cells via NKG2D-NKG2DL interactions, independent of antigen recognition, and identifies this pathway as a potential therapeutic target.