Author

P. E. Fecci

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

K. Ayasoufi· 3 shared D. Wilkinson· 2 shared E. C. Lerner· 2 shared J. Waibl Polania· 2 shared K. Woroniecka· 2 shared L. Wachsmuth· 2 shared M. Khasraw· 2 shared S. J. Lorrey· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersImmunology

K. Ayasoufi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models

K. Singh, K. M. Hotchkiss, S. L. Cook, P. Noldner, Y. Zhou, E. M. Moelker, C. O. Railton, E. E. Blandford, B. J. Puviindran, S. E. Wallace, P. K. Norberg, G. E. Archer, B. H. Shaz, K. Ayasoufi, J. H. Sampson, , P. E. Fecci

This study shows that IL-7-expanded autologous lymphocytes increase VLA-4 expression and accumulate in glioblastoma tumors, enhancing the effectiveness of T cell-based therapies.

bioRxiv · Apr 1, 2024Cancer Biology

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

S. J. Lorrey, L. Wachsmuth, J. Finlay, C. Neff, K. Ayasoufi, J. Waibl Polania, A. Hoyt-Miggelbrink, M. Price, L. Rein, S. Dell, R. Reesman, X. Cui, A. Hawley, E. Lerner, D. Wilkinson, , P. E. Fecci

This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.

bioRxiv · Nov 2, 2023 · PreprintImmunology

Antigen presentation by tumor-associated macrophages drives tumor-infiltrating T cells from a progenitor exhaustion state to terminal exhaustion

J. Waibl Polania, A. M. Hoyt-Miggelbrink, W. H. Tomaszewski, L. P. Wachsmuth, S. J. Lorrey, D. S. Wilkinson, E. C. Lerner, K. Woroniecka, J. B. Finlay, K. Ayasoufi, P. E. Fecci

The paper identifies tumor-associated macrophages as key drivers of T cell exhaustion transition, showing their role in shifting progenitor exhausted T cells to terminal exhaustion and impacting immunotherapy response.

bioRxiv · Aug 11, 2023 · PreprintImmunology

A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8+ T Cells

E. C. Lerner, K. Woroniecka, V. D'Anniballe, D. Wilkinson, S. Lorrey, J. W. Polania, L. Wachsmuth, A. Miggelbrink, J. Raj, W. Tomaszewski, A. Mohan, X. Cui, M. Khasraw, M. D. Gunn, P. E. Fecci

This study shows CD8+ T cells can kill MHC-I-deficient tumor cells via NKG2D-NKG2DL interactions, independent of antigen recognition, and identifies this pathway as a potential therapeutic target.

bioRxiv · Feb 2, 2023 · PreprintImmunology

Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome

B. Otvos, T. J. Alban, M. M. Grabowski, D. Bayik, E. E. Mulkearns-Hubert, T. Radivoyevitch, a. Rabljenovic, S. Johnson, C. Androjna, A. M. Mohammadi, G. Barnett, M. S. Ahluwalia, M. A. Vogelbaum, P. E. Fecci, J. D. Lathia

The paper develops a mouse model to study how surgery and steroids affect immune responses in glioblastoma, finding systemic lymphocyte reduction and correlations with tumor growth and patient outcomes.

bioRxiv · Aug 12, 2020Cancer Biology