A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics
C. Ghosh, L. Popella, V. Dhamodharan, J. Jung, L. Barquist, C. Hoebartner, J. Vogel
This study compares seven chemically distinct antisense oligomers targeting Salmonella acpP, finding only PNA and PMO are effectively delivered by a KFF peptide to inhibit bacterial growth.
bioRxiv · Jul 11, 2023Microbiology