J. Jung

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

GENESIS CGDYN: large-scale coarse-grained MD simulation with dynamicload balancing for heterogeneous biomolecular systems

The paper introduces GENESIS CGDYN, a large-scale coarse-grained MD simulation tool with dynamic load balancing for heterogeneous biomolecular systems, demonstrating its application to IDP droplet fusions and large droplet formation.

A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics

This study compares seven chemically distinct antisense oligomers targeting Salmonella acpP, finding only PNA and PMO are effectively delivered by a KFF peptide to inhibit bacterial growth.

Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in ex-vivo and in vitro models of pulmonary fibrosis

This study shows Dextromethorphan reduces collagen deposition in fibrotic models by inhibiting collagen trafficking in the endoplasmic reticulum.

Halophilic nematodes live in America's Dead Sea

The paper reports the discovery of novel halophilic nematodes in microbialites of the Great Salt Lake, UT, expanding knowledge of halophile ecosystems and habitable limits of animals.

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow

This study identifies hybrid neutrophils with dendritic features in glioblastoma that suppress tumor growth and originate from skull bone marrow.

An alpaca-derived nanobody neutralizes the SARS-CoV-2 omicron variant

This paper identifies a nanobody that effectively neutralizes the SARS-CoV-2 Omicron variants BA.1 and BA.2, showing high affinity and pre-clinical promise.

An ERAD-independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis

This study identifies a novel ERAD-independent role for Dfm1 in sphingolipid homeostasis by regulating Orm2 export and degradation.

Ontogeny of risk assessment and escape-hatching performance by red-eyed treefrog embryos in two threat contexts

This study examines how red-eyed treefrog embryos develop risk assessment and hatching performance in response to flooding and mechanical cues, finding that development reduces risk assessment and improves hatching performance, with mechanical cues eliciting faster responses.

INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors

The paper introduces INRI-seq, a cell-free Ribo-seq method to study translation initiation and off-target effects of antisense inhibitors in E. coli.

Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli

This study systematically evaluates PNA-based antisense antibiotics targeting essential genes in UPEC, identifying effective targets and revealing bacterial responses to PNA conjugates.

Derlin Dfm1 Employs a Chaperone Function to Resolve Misfolded Membrane Protein Stress

The paper identifies a chaperone function of Dfm1 in resolving misfolded membrane protein stress in yeast, independent of Cdc48 and distinct from its previously known role in protein dislocation.

Implementation of residue-level coarse-grained models in GENESIS for large-scale molecular dynamics simulations

The paper implements residue-level coarse-grained models in GENESIS to enable large-scale molecular dynamics simulations of biomolecules, improving computational efficiency and handling heterogeneous systems.

Carbohydrate sulfation as a mechanism for fine-tuning Siglec ligands

This study shows that specific sulfate modifications on Siglec ligands, mediated by CHSTs, can enhance or reduce Siglec binding, with implications for cancer immune evasion.

Clinical and immunological signatures of severe COVID-19 in previously healthy patients with clonal hematopoiesis

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

The Inherent Flexibility of Receptor Binding Domains in SARS-CoV-2 Spike Protein

This study identifies multiple conformational states of the SARS-CoV-2 Spike protein's receptor binding domain through molecular dynamics simulations, highlighting structural flexibility important for drug and vaccine design.

Concentration of intraflagellar transport proteins at the ciliary base is required for proper train injection

The paper shows that concentrating IFT proteins at the flagellum base is necessary for proper IFT train injection in Trypanosoma brucei.

Coordinated regulation of WNT/β-catenin, c-Met, and Integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits

This study identifies miR-193b as a key regulator of WNT/β-catenin, c-Met, and integrin pathways in TNBC, showing its strong repressive effect on metastatic traits.

Coordinated changes in glycosylation regulate the germinal centre through CD22

This study shows that glycan remodeling and CD22 downregulation are essential for proper germinal center function, including plasma cell output and antibody affinity maturation.

Development of Small Molecule Inhibitors Targeting PBX1 Transcription Signaling as a Novel Cancer Therapeutic Strategy

This study develops small molecule inhibitors targeting PBX1 transcription signaling, showing they suppress cancer cell growth and re-sensitize resistant tumors.

A high throughput SEC23 functional interaction screen reveals a role for focal adhesion and extracellular matrix signalling in the regulation of COPII subunit SEC23A

The paper screens 378 cytoskeleton-associated proteins for functional interactions with COPII subunits SEC23A and SEC23B, identifying regulators linked to focal adhesion and ECM signaling.

WNK1 Enhances Migration and Invasion in Breast Cancer Models

This study shows that inhibiting WNK1 reduces migration, invasion, and metastasis in breast cancer models.

Cysteine is a limiting factor for glioma proliferation and survival

This study shows that glioma cells depend on exogenous cysteine/cystine, and dietary restriction extends survival in a mouse model, though tumors can later compensate by synthesizing glutathione.

A Versatile Soluble Siglec Scaffold for Sensitive and Quantitative Detection of Glycan Ligands

This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.

Stereotypic Neutralizing VH Clonotypes Against SARS-CoV-2 RBD in COVID-19 Patients and the Healthy Population

The paper identifies stereotypic VH clonotypes against SARS-CoV-2 RBD in patients and healthy individuals, showing their pre-existing presence in the healthy population.

CRISPR-targeted display of functional T cell receptors enables engineering of enhanced specificity and prediction of cross-reactivity

The paper introduces a CRISPR-based platform to engineer TCRs with enhanced specificity and predict cross-reactivity by profiling mutational landscapes and screening TCR libraries.

Characterization of the exopolysaccharide biosynthesis pathway in Myxococcus xanthus

This paper characterizes the exopolysaccharide (EPS) biosynthesis pathway in Myxococcus xanthus, identifying key enzymes and showing their role in motility and fruiting body formation.

Unoccupied aerial system enabled functional modeling of maize (Zea mays L.) height reveals dynamic expression of loci associated to temporal growth.

This paper uses UAS to model maize growth and identifies temporal QTL associated with plant height, showing dynamic expression patterns over time.

Pinealectomy increases thermogenesis and decreases lipogenesis

This study shows that pinealectomy in rats increases thermogenesis in brown adipose tissue and decreases lipogenesis in white adipose tissue and the liver.

High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations

The paper presents high-resolution cryo-EM structures of multiple human norovirus strains, revealing size variations and structural polymorphism.