Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5
D. J. Doorduijn, M. V. Lukassen, M. F. L. van 't Wout, V. Franc, M. Ruyken, B. W. Bardoel, A. J. R. Heck, S. H. M. Rooijakkers
The paper investigates how soluble MAC (sMAC) is formed during bacterial infections, finding that MAC-resistant bacteria convert C5 into C5b more efficiently and release sMAC, which can lyse bystander erythrocytes.
bioRxiv · Dec 15, 2021Microbiology