Author

E. C. Couves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1

Frequent Co-Authors

D. Bubeck· 2 shared A. J. R. Heck· 1 shared A. Menny· 1 shared E. W. Tate· 1 shared J. K. Bickel· 1 shared M. V. Lukassen· 1 shared P. J. Stansfeld· 1 shared S. Gardner· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

D. Bubeck

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2 papers

Recent·Most cited

Structural basis for membrane attack complex inhibition by CD59

E. C. Couves, S. Gardner, T. B. Voisin, J. K. Bickel, P. J. Stansfeld, E. W. Tate, D. Bubeck

This study reveals how CD59 inhibits MAC pore formation by binding C8 and deflecting C9, using cryo-EM structures and simulations.

bioRxiv · Sep 5, 2022Immunology

Structural basis for how sMAC is packaged for clearance

A. Menny, M. V. Lukassen, E. C. Couves, V. Franc, A. J. R. Heck, D. Bubeck

The paper determines the structure of soluble membrane attack complex (sMAC) using cryoEM and XL-MS, revealing how clusterin inhibits its polymerization and how C9 is trapped in an intermediate conformation.

bioRxiv · Apr 6, 2021 · PreprintBiophysics