Biasing HER4 Tyrosine Kinase Signaling with Antibodies: Induction of Cell Death by Antibody-Dependent HER4 Intracellular Domain Trafficking
R. Lanotte, V. Garambois, N. Gaborit, C. Larbouret, A. Musnier, P. Martineau, A. Pelegrin, T. Chardes
This paper shows that anti-HER4 antibodies can mimic NRG1's tumor suppressor effects by inducing 4ICD mitochondrial trafficking and cell death in cancer cells.
bioRxiv · Dec 20, 2019Cancer Biology