Author

V. Grinkevich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Cerutti· 1 shared A. Cicconi· 1 shared A. Galbiati· 1 shared A. Inga· 1 shared A. Karlen· 1 shared A. Okorokov· 1 shared C. Spinnler· 1 shared D. Ebner· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Cerutti

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Author profile →

2 papers

Recent·Most cited

Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

G. Rodriguez-Berriguete, M. Ranzani, R. Prevo, R. Puliyadi, N. Machado, H. R. Bolland, V. Millar, D. Ebner, M. Boursier, A. Cerutti, A. Cicconi, A. Galbiati, D. Grande, V. Grinkevich, J. Majithiya, , G. S. Higgins

This study shows that Polθ inhibitors ART558 and ART899 radiosensitize tumor cells without affecting normal fibroblasts, suggesting potential for safe cancer radiotherapy.

bioRxiv · Sep 27, 2022Cancer Biology

Novel allosteric mechanism of dual p53/MDM2 and p53/MDM4 inhibition by a small molecule

V. Grinkevich, V. Aparna, K. Fawkner, N. Issaeva, V. Andreotti, E. R. Dickinson, E. Hedstrom, C. Spinnler, A. Inga, L.-G. Larsson, A. Karlen, M. Wilhelm, P. Barran, A. Okorokov, G. Selivanova, J. E. Zawacka-Pankau

This paper identifies a novel allosteric mechanism by which RITA and PpIX inhibit p53/MDM2 and p53/MDM4 interactions, offering a new approach for p53 reactivation in cancer therapy.

bioRxiv · Dec 24, 2021Biochemistry