Author

G. Rodriguez-Berriguete

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. Cerutti· 1 shared A. Cicconi· 1 shared A. Galbiati· 1 shared A. Kiltie· 1 shared A. N. Singh· 1 shared A. Ruggiano· 1 shared B. Vaz· 1 shared D. Ebner· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Cerutti

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

G. Rodriguez-Berriguete, M. Ranzani, R. Prevo, R. Puliyadi, N. Machado, H. R. Bolland, V. Millar, D. Ebner, M. Boursier, A. Cerutti, A. Cicconi, A. Galbiati, D. Grande, V. Grinkevich, J. Majithiya, , G. S. Higgins

This study shows that Polθ inhibitors ART558 and ART899 radiosensitize tumor cells without affecting normal fibroblasts, suggesting potential for safe cancer radiotherapy.

bioRxiv · Sep 27, 2022Cancer Biology

SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

B. Vaz, A. Ruggiano, M. Popovic, G. Rodriguez-Berriguete, S. Kilgas, A. N. Singh, I. Torrecilla, G. Higgins, A. Kiltie, K. Ramadan

This study identifies SUMO-1 modification of DNA-protein crosslinks (DPCs) as a mechanism that promotes SPRTN proteolysis over homologous recombination, preventing genomic instability.

bioRxiv · Feb 14, 2020 · PreprintCell Biology