Cell BiologybioRxiv
Ligand binding promiscuity of αVβ3 integrin is enlarged in response to mechanical force
M. Bachmann, M. Schäfer, V. Mykuliak…·M. Bastmeyer
This study shows that mechanical force increases the ligand promiscuity of αVβ3 integrin by enabling binding to fibronectin through conformational changes.
DOI 10.1242/jcs.242404