Ligand binding promiscuity of αVβ3 integrin is enlarged in response to mechanical force
M. Bachmann, M. Schäfer, V. Mykuliak, M. Ripamonti, L. Heiser, K. Weissenbruch, S. Krübel, C. M. Franz, V. Hytönen, B. Wehrle-Haller, M. Bastmeyer
This study shows that mechanical force increases the ligand promiscuity of αVβ3 integrin by enabling binding to fibronectin through conformational changes.
bioRxiv · Nov 20, 2018Cell Biology