Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ
Y.-C. Yen, Y. Li, C.-L. Chen, T. Klose, V. J. Watts, C. W. Dessauer, J. J. G. Tesmer
This study reports cryo-EM structures of AC5 with Gβγ and proposes a mechanism for its isoform-specific regulation, linking it to motor function and potential drug development.
bioRxiv · May 2, 2023 · PreprintBiophysics