Author

C. W. Dessauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

Y. Li· 4 shared T. A. Baldwin· 2 shared A. B. Sundaram· 1 shared A. G. Carbajal· 1 shared A. Inoue· 1 shared A. M. Lazar· 1 shared A. Marsden· 1 shared A. Plueckthun· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiochemistry

Y. Li

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Author profile →

5 papers

Recent·Most cited

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ

Y.-C. Yen, Y. Li, C.-L. Chen, T. Klose, V. J. Watts, C. W. Dessauer, J. J. G. Tesmer

This study reports cryo-EM structures of AC5 with Gβγ and proposes a mechanism for its isoform-specific regulation, linking it to motor function and potential drug development.

bioRxiv · May 2, 2023 · PreprintBiophysics

Stablization of Interdomain Interactions in G protein αi Subunits Determines Gαi Subtype Signaling Specificity

T. Lefevre, W. Wei, E. Mukhaleva, S. P. M. Venkata, N. R. Chandan, S. Abraham, Y. Li, C. W. Dessauer, N. Vaidehi, A. Smrcka

This study identifies an amino acid difference that stabilizes interdomain interactions in Gi1 but not Gi2, leading to differences in effector activation and signaling specificity.

bioRxiv · Mar 10, 2023Pharmacology & Toxicology

Popeye Domain-Containing Protein 1 Scaffolds a Complex of Adenylyl Cyclase 9 and the Two-Pore-Domain Potassium Channel TREK-1 in Heart

T. A. Baldwin, Y. Li, A. Marsden, R. F. R. Schindler, M. Zhang, A. G. Carbajal, M. A. Garcia, V. R. Venna, T. Brand, C. W. Dessauer

The paper identifies POPDC1 as a novel scaffold for AC9 that regulates heart rate by interacting with TREK-1 in an isoproterenol-dependent manner.

bioRxiv · Dec 21, 2021 · PreprintBiochemistry

Structural basis of adenylyl cyclase 9 activation

C. Qi, P. Lavriha, V. Mehta, B. Khanppnavar, I. Mohammed, Y. Li, M. Lazaratos, J. V. Schaefer, B. Dreier, A. Plueckthun, A.-N. Bondar, C. W. Dessauer, V. M. Korkhov

The paper presents cryo-EM structures of AC9 in different states to reveal activator-induced conformational changes essential for its activation.

bioRxiv · Aug 11, 2021Biochemistry

G protein-regulated endocytic trafficking of adenylyl cyclase type 9

A. M. Lazar, R. Irannejad, T. A. Baldwin, A. B. Sundaram, J. S. Gutkind, A. Inoue, C. W. Dessauer, M. Von Zastrow

This study shows AC9 traffics from the plasma membrane to endosomes via Gs, unlike AC1, and contributes to cAMP production from endosomes.

bioRxiv · Apr 23, 2020Cell Biology