Author

Y.-C. Yen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1 Organism:zebrafish· 1

Frequent Co-Authors

J. J. G. Tesmer· 3 shared C.-l. Chen· 2 shared T. Klose· 2 shared A. B. Long· 1 shared A. Lee· 1 shared A. Poddar· 1 shared B. R. Myers· 1 shared C. D. Arveseth· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

J. J. G. Tesmer

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade

M. F. Walker, J. Zhang, W. Steiner, P.-I. Ku, J.-F. Zhu, Z. Michaelson, Y.-C. Yen, A. Lee, A. B. Long, M. J. Casey, A. Poddar, I. B. Nelson, C. D. Arveseth, F. Nagel, R. Clough, , B. R. Myers

This study identifies GRK2-mediated phosphorylation of SMO in the primary cilium as a critical step initiating SMO-PKA signaling in the Hedgehog pathway.

bioRxiv · May 10, 2023Cell Biology

Molecular basis for Gβγ-mediated activation ofphosphoinositide 3-kinase γ

C.-l. Chen, R. Syahirah, S. Ravala, Y.-C. Yen, T. Klose, Q. Deng, J. J. G. Tesmer

This study identifies two distinct Gβγ binding sites on PI3Kγ and shows how Gβγ activates the enzyme through conformational changes and allosteric control.

bioRxiv · May 4, 2023Biophysics

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ

Y.-C. Yen, Y. Li, C.-L. Chen, T. Klose, V. J. Watts, C. W. Dessauer, J. J. G. Tesmer

This study reports cryo-EM structures of AC5 with Gβγ and proposes a mechanism for its isoform-specific regulation, linking it to motor function and potential drug development.

bioRxiv · May 2, 2023 · PreprintBiophysics