Author

C.-L. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. J. G. Tesmer· 3 shared T. Klose· 2 shared Y.-C. Yen· 2 shared A.-M. Lachages· 1 shared B. Jin· 1 shared C. Thermes· 1 shared C. W. Dessauer· 1 shared C.-C. Chuang· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiophysics

J. J. G. Tesmer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

S. K. Ravala, S. R. Adame-Garcia, S. Li, C.-L. Chen, M. A. Cianfrocco, J. S. Gutkind, J. N. Cash, J. J. G. Tesmer

This study identifies structural changes in P-Rex1 upon activation by PIP3 and inhibition by IP4, revealing how these interactions regulate its GEF activity.

bioRxiv · Sep 15, 2023Biochemistry

Directing polymorph specific calcium carbonate formation with de novo protein templates

F. A. Davila Hernandez, B. Jin, H. Pyles, S. Zhang, Z. Wang, T. F. Huddy, C.-L. Chen, J. J. De Yoreo, D. Baker

De novo designed protein templates promote nucleation of nano-calcite and direct its growth by oriented particle attachment.

bioRxiv · Jun 9, 2023Biochemistry

Molecular basis for Gβγ-mediated activation ofphosphoinositide 3-kinase γ

C.-l. Chen, R. Syahirah, S. Ravala, Y.-C. Yen, T. Klose, Q. Deng, J. J. G. Tesmer

This study identifies two distinct Gβγ binding sites on PI3Kγ and shows how Gβγ activates the enzyme through conformational changes and allosteric control.

bioRxiv · May 4, 2023Biophysics

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ

Y.-C. Yen, Y. Li, C.-L. Chen, T. Klose, V. J. Watts, C. W. Dessauer, J. J. G. Tesmer

This study reports cryo-EM structures of AC5 with Gβγ and proposes a mechanism for its isoform-specific regulation, linking it to motor function and potential drug development.

bioRxiv · May 2, 2023 · PreprintBiophysics

Pantothenate Kinase 4 Governs Lens Epithelial Fibrosis by Negatively Regulating PKM2 Related Glycolysis

X. Li, L.-L. Luo, R.-F. Li, C.-L. Chen, M. Sun, S. Lin

This study identifies PANK4 as a regulator of lens epithelial fibrosis through its control of PKM2-related glycolysis and EMT.

bioRxiv · Aug 2, 2022Cell Biology

Unscheduled origin building in S-phase upon tight CDK1 inhibition suppresses CFS instability

O. BRISON, S. Gnan, D. Azar, M. Schmidt, S. KOUNDRIOUKOFF, S. El-Hilali, Y. Jaszczyszyn, A.-M. Lachages, C. Thermes, C.-L. Chen, M. Debatisse

The paper shows that tight CDK1 inhibition during S-phase reduces CFS instability by promoting extra replication origins in under-replicated regions.

bioRxiv · Nov 19, 2020 · PreprintCell Biology

Mutant glucocorticoid receptor binding elements on Interleukin-6 promoter regulate dexamethasone effects

W.-T. Chang, M.-Y. Hong, C.-L. Chen, C.-C. Tsai, C.-Y. Hwang, C.-C. Chuang

The paper identifies GR2/3 binding sites on the IL-6 promoter that regulate dexamethasone effects on LPS-induced inflammation.

bioRxiv · Jun 24, 2020Immunology