LncRNA H19 Upregulation Links Hypoplastic Left Heart Syndrome to Impaired PINK1/Parkin-Mediated Mitophagy and Ischemic Vulnerability
Xuebin Fu, Conrad L. Epting, Anshuman Sinha, Michael C. Mongé, Ming Zhao, Kristofor E. Glinton, Swetha Thirukannamangai Krishnan, My Linh Thi Nguyen, V. Joseph Dudley, Gregory B. Waypa, Pedro G. Lara, Tarek Kishawi, Connor W. Lantz, David Scott Winlaw, Paul T. Schumacker, , Zhi‐Dong Ge
This study shows H19 upregulation in HLHS impairs mitophagy and increases ischemic vulnerability in immature hearts and cardiomyocytes.
bioRxiv · Dec 19, 2025 · PreprintGenomics