Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
Q. Ong, L. T. R. Lim, C. Goh, Y. Liao, S. E. Chan, C. J. Y. Lim, V. Kam, J. Yap, T. Tseng, R. Desrouleaux, L. C. Wang, S. G. Ler, S. L. Lim, S. Kim, R. M. Sobota, , X. Yang
This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.
bioRxiv · May 12, 2024Cell Biology