Author

L. C. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R. Sobota· 3 shared R. M. Sobota· 2 shared A. M. Bennett· 1 shared A. Westermann· 1 shared B. Han· 1 shared B. Kerouantan· 1 shared B. Mika-Gospodorz· 1 shared B. Reversade· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersCell Biology

R. Sobota

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT

Q. Ong, L. T. R. Lim, C. Goh, Y. Liao, S. E. Chan, C. J. Y. Lim, V. Kam, J. Yap, T. Tseng, R. Desrouleaux, L. C. Wang, S. G. Ler, S. L. Lim, S. Kim, R. M. Sobota, , X. Yang

This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.

bioRxiv · May 12, 2024Cell Biology

TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport

H. Wu, L. C. Wang, B. Sow, D. Leow, J. Zhu, K. Gallo, K. Wilsbach, R. Gupta, L. Ostrow, C. Yeo, R. Sobota, R. Li

The paper identifies TDP43 aggregation at ER-exit sites as a cause of impaired ER-to-Golgi transport in ALS.

bioRxiv · Jan 24, 2024Cell Biology

Unbiased phosphoproteomics analysis unveils modulation of insulin signaling by extramitotic CDK1 kinase activity in human myotubes

B. Han, G. X. Li, W. L. Liew, E. Chan, S. Huang, C. M. Khoo, M. K.-S. Leow, Y. S. Lee, T. Zhao, L. C. Wang, R. M. Sobota, H. Choi, M. H. Liu, K. P. Kim, E. S. Tai

The paper uses phosphoproteomics to show that CDK1 activity modulates insulin signaling and glucose uptake in human myotubes, with group-specific phosphorylation changes observed.

bioRxiv · Jun 30, 2023 · PreprintPhysiology

BRAWNIN: A sORF-encoded Peptide Essential for Vertebrate Mitochondrial Complex III Assembly

S. Zhang, C. Liang, C. Mary, B. Kerouantan, J. Francisco, N. S. Jagannathan, V. Olexiouk, J. H. Peh, C. Tang, G. Fidelito, S. Nama, R.-K. Cheng, C. L. Wee, L. C. Wang, P. D. Roggli, , L. Ho

The paper identifies BRAWNIN, a sORF-encoded peptide critical for vertebrate mitochondrial complex III assembly, showing its role in oxidative phosphorylation and metabolic function.

bioRxiv · Jan 31, 2020 · PreprintCell Biology

Dual RNA-seq provides insight into the biology of the neglected intracellular human pathogen Orientia tsutsugamushi

B. Mika-Gospodorz, S. Giengkam, A. Westermann, J. Wongsantichon, W. B. Kion-Crosby, S. Chuenklin, L. C. Wang, P. Sunyakumthorn, R. Sobota, S. Subbian, J. Vogel, L. Barquist, J. Salje

The paper uses dual RNA-seq to study the transcriptional architecture and host-pathogen interactions of Orientia tsutsugamushi, identifying antisense regulation and strain-specific immune responses.

bioRxiv · Oct 29, 2019Microbiology