Author

A. M. Bennett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 2 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:virus· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

X. Yang· 4 shared A. Spencer· 2 shared C. E. Xirouchaki· 2 shared C. Fernandez-Hernando· 2 shared H. H. Chang· 2 shared I. Garratt· 2 shared J. Dunning· 2 shared J. V. Rocheleau· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersPhysiology

X. Yang

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Author profile →

8 papers

Recent·Most cited

Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT

Q. Ong, L. T. R. Lim, C. Goh, Y. Liao, S. E. Chan, C. J. Y. Lim, V. Kam, J. Yap, T. Tseng, R. Desrouleaux, L. C. Wang, S. G. Ler, S. L. Lim, S. Kim, R. M. Sobota, , X. Yang

This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.

bioRxiv · May 12, 2024Cell Biology

MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention

B. Qiu, A. Lawan, C. E. Xirouchaki, J.-S. Yi, M. Robert, L. Zhang, W. Brown, C. Fernandez-Hernando, X. Yang, A. M. Bennett

This study shows MKP1 suppresses AMPK activity via LKB1 nuclear retention, promoting NASH by inducing hepatocyte death and inflammation.

bioRxiv · Jul 10, 2023Physiology

Hepatocyte-specific miR-33 deletion attenuates NAFLD-NASH-HCC progression

P. FERNANDEZ TUSSY, J. Sun, M. P. Cardelo, N. L. Price, L. Goedeke, C. E. Xirouchaki, X. Yang, O. Pastor-Rojo, A. M. Bennett, T. Tiganis, Y. Suarez, C. Fernandez-Hernando

This study shows that deleting miR-33 in hepatocytes reduces NAFLD progression to NASH, fibrosis, and HCC by improving lipid metabolism and mitochondrial function.

bioRxiv · Jan 18, 2023 · PreprintPhysiology

Targeting Apollo-NADP+ to image NADPH generation in pancreatic beta-cell organelles

H. H. Chang, A. M. Bennett, W. D. Cameron, E. Floro, A. Au, C. M. McFaul, C. M. Yip, J. V. Rocheleau

The paper develops organelle-targeted Apollo-NADP+ sensors to study glucose- and glutamine-stimulated NADPH production in pancreatic beta-cell organelles, revealing mitochondria's key role in NADPH generation.

bioRxiv · Apr 27, 2022Cell Biology

A Comparison of Persistence of SARS-CoV-2 Variants on Stainless Steel

T. Pottage, I. Garratt, O. Onianwa, A. Spencer, S. E. Paton, J. Dunning, A. M. Bennett

This study compares the persistence of SARS-CoV-2 variants on stainless steel to an established isolate, finding no significant difference in inactivation rates.

bioRxiv · Apr 8, 2021Microbiology

Persistence of SARS-CoV-2 virus and viral RNA on hydrophobic and hydrophilic surfaces and investigating contamination concentration

S. E. Paton, A. Spencer, I. Garratt, K.-A. Thompson, I. Dinesh, P. AranegaBou, D. Stevenson, S. O. Clark, J. Dunning, A. M. Bennett, T. Pottage

This study examines the persistence of SARS-CoV-2 viability and RNA on different surfaces, finding that viability declines faster than RNA stability and is independent of initial concentration.

bioRxiv · Mar 11, 2021 · PreprintMicrobiology

Cell segmentation using deep learning: comparing label and label-free approaches using hyper-labeled image stacks

W. D. Cameron, A. M. Bennett, C. V. Bui, H. H. Chang, J. V. Rocheleau

This study compares label and label-free deep learning approaches for cell segmentation using hyper-labeled image stacks, finding fluorescence-based methods are more accurate but label-free models can be more robust with inconsistent labeling.

bioRxiv · Jan 9, 2020 · PreprintBioengineering

O-GlcNAc transferase suppresses necroptosis and liver fibrosis

B. Zhang, M.-D. Li, R. Yin, Y. Liu, Y. Yang, K. A. Mitchell-Richards, J. H. Nam, R. Li, L. Wang, Y. Iwakiri, D. Chung, M. E. Robert, B. E. Ehrlich, A. M. Bennett, J. Yu, , X. Yang

This study identifies O-GlcNAc transferase as a suppressor of hepatocyte necroptosis and liver fibrosis, using both human and mouse models.

bioRxiv · Jan 14, 2019Physiology