The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113
D. Podlesainski, E. T. Adeniyi, Y. Groener, F. Schulz, V. Krisilia, N. Rehberg, T. Richter, D. Sehr, H. Xie, V. E. Simons, A.-L. Kiffe-Delf, F. Kaschani, T. R. Ioerger, M. Kaiser, R. Kalscheuer
This study identifies callyaerins as antitubercular agents targeting the M. tuberculosis-specific protein Rv2113, showing efficacy against drug-resistant strains with minimal cytotoxicity.
bioRxiv · Jul 12, 2023 · PreprintMicrobiology