Hypercholesterolemia Impairs Clearance of Extracellular DNA and Promotes Inflammation and Atherosclerotic Plaque Progression
U. K. Dhawan, P. Bhattacharya, S. Narayanan, V. Manickam, A. Aggarwal, M. Subramanian
This study shows hypercholesterolemia impairs DNA clearance by reducing DNase activity, leading to inflammation and atherosclerosis progression in mice and humans.
bioRxiv · Oct 5, 2020 · PreprintImmunology