The integrated stress response induces R-loops and hinders replication fork progression
J. A. M. Y. Choo, D. Schloesser, V. Manzini, A. Magerhans, M. Dobbelstein
This paper shows that the integrated stress response (ISR) inhibits DNA replication by causing histone deficiency and R-loop formation, linking ISR to DNA replication regulation.
bioRxiv · Mar 11, 2020Cancer Biology