Author

M. Dobbelstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. A. M. Y. Choo· 2 shared A. Chari· 1 shared A. Dickmanns· 1 shared A. Kleeberg· 1 shared A. Magerhans· 1 shared A. R. Pearson· 1 shared B. Ross· 1 shared B. Wollnik· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

J. A. M. Y. Choo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress

J. Jansen, K. E. Bohnsack, S. Boehlken-Fascher, M. T. Bohnsack, M. Dobbelstein

bioRxiv · Dec 29, 2023 · PreprintCancer Biology

Redox regulation of the SARS-CoV-2 main protease provides new opportunities for drug design

K. Tittmann, L.-M. Funk, G. Poschmann, A. Chari, F. Rabe von Pappenheim, K. M. Stegmann, A. Dickmanns, N. Eulig, M. Wensien, E. Paknia, G. Heyne, E. Penka, A. R. Pearson, C. Berndt, T. Fritz, , U. Curth

This study identifies redox regulation of SARS-CoV-2 Mpro and discovers antiviral reagents that mimic redox switching, suggesting new drug targets.

bioRxiv · Apr 18, 2022 · PreprintBiochemistry

Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair

M. Silva-Garcia, O. Bolgi, B. Ross, E. Pilla, K. Vijayalakshmi, M. Killisch, N. Stark, C. Lenz, M. Spitzner, M. D. Gorrell, M. Grade, H. Urlaub, M. Dobbelstein, R. Huber, R. Geiss-Friedlander

This study identifies DPP9 as a regulator of BRCA2 stability and DNA-damage repair by promoting its degradation via the N-degron pathway.

bioRxiv · Aug 24, 2020Biochemistry

The integrated stress response induces R-loops and hinders replication fork progression

J. A. M. Y. Choo, D. Schloesser, V. Manzini, A. Magerhans, M. Dobbelstein

This paper shows that the integrated stress response (ISR) inhibits DNA replication by causing histone deficiency and R-loop formation, linking ISR to DNA replication regulation.

bioRxiv · Mar 11, 2020Cancer Biology

Centrosome impairment causes DNA replication stress through MLK3/MK2 signaling and R-loop formation

Z. Tayeh, K. Stegmann, A. Kleeberg, M. Friedrich, J. A. M. Y. Choo, B. Wollnik, M. Dobbelstein

bioRxiv · Jan 9, 2020 · PreprintCell Biology