Chop/Ddit3 depletion in β-cells alleviates ER stress and corrects hepatic steatosis
J. Yong, V. P. Parekh, J. Nayak, Z. Chen, C. Lebeaupin, J. Zhang, T. P. Prakash, S. Murray, S. Guo, J. E. Ayala, L. S. Satin, R. J. Kaufman
This study shows that deleting Chop/Ddit3 in β-cells reduces ER stress and corrects fatty liver disease in T2D without affecting glucose homeostasis.
bioRxiv · Jan 2, 2020 · PreprintPhysiology