Author

J. E. Ayala

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Physiology· 6

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:clustering· 2 Research Focus:host-pathogen & immune response· 2 Assay:behavioral assay· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. J. Ellis· 2 shared D. Liu· 2 shared M. B. Bales· 2 shared R. P. Ceddia· 2 shared S. Collins· 2 shared T. D. V. Le· 2 shared A. B. Watters· 1 shared A. I. Sullivan· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersPhysiology

B. J. Ellis

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6 papers

Recent·Most cited

Time dependent changes in feeding behavior and energy balance associated with weight gain in mice fed obesogenic diets

P. A. Fathi, M. B. Bales, J. E. Ayala

This study shows that mice on obesogenic diets initially attempt to maintain energy balance but eventually fail, leading to weight gain through increased meal size and frequency.

Obesity · Jun 27, 2024Peer-reviewedPhysiology

Liver Fibroblast Growth Factor 21 (FGF21) is Required for the Full Anorectic Effect of the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate Diets

T. D. V. Le, P. Fathi, A. B. Watters, B. J. Ellis, N. Bozadjieva-Kramer, M. B. Perez, A. I. Sullivan, J. P. Rose, L. L. Baggio, J. Koehler, J. L. Brown, M. B. Bales, K. G. Nwaba, J. E. Campbell, D. J. Drucker, , J. E. Ayala

This study shows that FGF21 is necessary for liraglutide's full weight loss effect in male mice on high-carbohydrate diets, mediated through neuronal pathways.

bioRxiv · Jan 3, 2023 · PreprintPhysiology

Glucagon-Like Peptide-1 Receptor Activation Stimulates PKA-Mediated Phosphorylation of Raptor and this Contributes to the Weight Loss Effects of Liraglutide

T. D. V. Le, D. Liu, G.-L. K. Besing, R. Raghavan, B. J. Ellis, R. P. Ceddia, S. Collins, J. E. Ayala

This study shows that GLP-1R agonist liraglutide induces PKA-mediated phosphorylation of Raptor at Ser791, which contributes to its weight loss effect.

bioRxiv · Apr 21, 2022Physiology

Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

R. P. Ceddia, Z. Zurawski, A. Thompson Gray, F. Adegboye, A. McDonald-Boyer, F. Shi, D. Liu, J. Maldonado, J. Feng, Y. Li, S. Alford, J. E. Ayala, O. P. McGuinness, S. Collins, H. E. Hamm

This paper shows that disrupting the Gβγ-SNAP25 interaction improves insulin action, promotes adipocyte browning, and protects against diet-induced obesity in mice.

bioRxiv · Apr 29, 2020 · PreprintPhysiology

Chop/Ddit3 depletion in β-cells alleviates ER stress and corrects hepatic steatosis

J. Yong, V. P. Parekh, J. Nayak, Z. Chen, C. Lebeaupin, J. Zhang, T. P. Prakash, S. Murray, S. Guo, J. E. Ayala, L. S. Satin, R. J. Kaufman

This study shows that deleting Chop/Ddit3 in β-cells reduces ER stress and corrects fatty liver disease in T2D without affecting glucose homeostasis.

bioRxiv · Jan 2, 2020 · PreprintPhysiology

Metabolite profile and mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice

X. Zhang, M. B. Trevino, M. Wang, S. J. Gardell, J. E. Ayala, X. Han, D. P. Kelly, B. H. Goodpaster, R. B. Vega, P. M. Coen

This study identifies mitochondrial dysfunction and metabolic dysregulation as factors underlying poor muscle recovery in old mice after hind limb unloading.

bioRxiv · Aug 31, 2017Physiology