M. P. Wear

Semi-synthetic glycoconjugate vaccine candidate against Cryptococcus neoformans

This paper presents two semi-synthetic glycoconjugate vaccines targeting Cryptococcus neoformans GXM, showing immunogenicity and cross-reactivity in mice.

The structure of a C. neoformans polysaccharide motif recognized by protective antibodies: a combined NMR and MD study

This study uses NMR and MD simulations to determine the structure of a synthetic C. neoformans polysaccharide, revealing its extended conformation and structural features recognized by protective antibodies.

Lyophilization induces alterations in cryptococcal exopolysaccharide resulting in reduced antibody binding

This study shows that lyophilization alters the structure of Cryptococcus neoformans exopolysaccharide, reducing antibody binding.

Cryptococcus neoformans capsule regrowth experiments reveal dynamics of enlargement and architecture

This study isolates and characterizes Cryptococcus neoformans capsule polysaccharides using physical and enzymatic methods, revealing that the capsule is assembled from smaller polymers added distally.

Hinge Influences in Murine IgG Binding to Cryptococcus neoformans Capsule

This paper investigates how the constant region, specifically the hinge, influences antigen binding in murine IgG antibodies targeting Cryptococcus neoformans capsule polysaccharides, showing that the hinge is necessary but not sufficient for binding differences between isotypes.

Exploring Cryptococcus neoformans capsule structure and assembly with a hydroxylamine-armed fluorescent probe

This study uses a hydroxylamine-armed fluorescent probe to investigate the structure and assembly of the Cryptococcus neoformans capsule, revealing reducing ends at the cell wall surface.