Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells
V. Perea, K. R. Baron, V. Dolina, G. Aviles, J. D. Rosarda, X. Guo, M. Kampmann, L. Wiseman
This study shows that halofuginone can compensate for PERK signaling deficiencies by promoting adaptive mitochondrial remodeling, while BtdCPU causes mitochondrial fragmentation.
bioRxiv · Mar 11, 2023Cell Biology